空白脂质体的理化性质与 Cell-Del® 氯膦酸盐脂质体保持一致，内部未包封活性氯膦酸盐。游离的氯膦酸盐无法穿透细胞膜，因此不会造成细胞死亡。本品适用于巨噬细胞耗竭相关实验，作为阴性对照使用。
• 乳白色混悬即用型液体
• 可通过多种途径给药
• 用于巨噬细胞耗竭/清除实验的阴性对照
• 荷兰生产，原装进口
| 品牌 | 产地 | 品名 | 货号 | 规格 | 库存 | 目录价 | 促销价 |
| Biotarget | 荷兰生产 | Cell-Del®Control Liposomes(PBS)空白对照脂质体 | C283502 | 2 mL | 现货 | 952.00 | 810.00 |
| Biotarget | 荷兰生产 | Cell-Del®Control Liposomes(PBS)空白对照脂质体 | C283505 | 5 mL | 现货 | 1652.00 | 1405.00 |
| Biotarget | 荷兰生产 | Cell-Del®Control Liposomes(PBS)空白对照脂质体 | C283509 | 10 mL | 现货 | 2252.00 | 1915.00 |
空白对照脂质体（Cell-Del®Control Liposomes），理化性质与 Cell-Del® 氯膦酸盐脂质体完全一致，内部未包裹活性成分氯膦酸盐，适用于巨噬细胞清除相关实验，作为阴性对照使用。
脂质体(Liposomes)是一种人工膜，由磷脂和胆固醇构成。一般直径在25nm-1um之间。细胞体外(invitro)吞噬实验显示，随着脂质体(Liposome)的直径从100nm到1um，细胞吞噬的脂质体(Liposomes)随之增多，直至高达2um；动物体内(invivo)实验显示，随着直径增大，体内吞噬的脂质体(Liposomes)更多。脂质体(Liposomes)和巨噬细胞（Macrophages）间有最小的间隙，辅以改变脂质体(Liposomes)表面的电荷，尤其是负电荷，能更好促进巨噬细胞对脂质体的吞噬。采用多室的脂质体结构，让包裹更多的药物，从而到达效应的阈浓度。
外观：乳白色混悬液
保质期：未开封试剂瓶置于 2~8℃环境下，有效期 6 个月
脂质组分：磷脂酰胆碱、胆固醇
平均粒径：0.5~3.5 微米
包裹药物：无
缓冲体系：磷酸盐缓冲液
pH 值：7.0~7.5
储存条件：4℃避光保存，严禁冷冻
运输方式：采用保温箱+蓝冰运输
注意事项
• 产品禁止冻存，避免低于0 ℃。
• 产品静置于冰箱中会出现分层现象（瓶底产生沉淀，上层为澄清液）。
• 使用前请轻柔摇晃，直至体系混合均匀，操作过程中避免产生气泡。
• 产品禁止分装。
• 产品避免接触破环脂质体结构的有机试剂和离子去垢剂。
0. Xia Y, Xie Y, Yu Z, Xiao H, Jiang G, Zhou X, Yang Y, Li X, Zhao M, Li L, Zheng M, Han S, Zong Z, Meng X, Deng H, Ye H, Fa Y, Wu H, Oldfield E, Hu X, Liu W, Shi Y, Zhang Y. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21. doi: 10.1016/j.cell.2018.08.070. Epub 2018 Sep 27. PMID: 30270039. PubMed 
(2018年，产品首次被Cell引用)
1. van Rooijen N, van Nieuwmegen R. Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. An enzyme-histochemical study. Cell Tissue Res. 1984;238(2):355-8. doi: 10.1007/BF00217308. PMID: 6239690. PubMed
2. van Rooijen N, van Nieuwmegen R, Kamperdijk EW. Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. Ultrastructural aspects of elimination of marginal zone macrophages. Virchows Arch B Cell Pathol Incl Mol Pathol. 1985;49(4):375-83. doi: 10.1007/BF02912114. PMID: 2867636. PubMed
3. Claassen E, Kors N, van Rooijen N. Immunomodulation with liposomes: the immune response elicited by liposomes with entrapped dichloromethylene-diphosphonate and surface-associated antigen or hapten. Immunology. 1987 Apr;60(4):509-15. PMID: 2953668; PMCID: PMC1453280. PubMed
4. van Rooijen N, Kors N, ter Hart H, Claassen E. In vitro and in vivo elimination of macrophage tumor cells using liposome-encapsulated dichloromethylene diphosphonate. Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;54(4):241-5. doi: 10.1007/BF02899217. PMID: 2895535. PubMed
5. van Rooijen N, Kors N, Kraal G. Characterization of cell populations, reappearing in the mouse spleen after elimination by liposome encapsulated dichloromethylene diphosphonate: reappearance of marginal zone lymphocytes is independent of marginal zone macrophages. Adv Exp Med Biol. 1988;237:889-93. doi: 10.1007/978-1-4684-5535-9_133. PMID: 2978212. PubMed
6. van Rooijen N, Kors N, Kraal G. Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination. J Leukoc Biol. 1989 Feb;45(2):97-104. doi: 10.1002/jlb.45.2.97. PMID: 2521666. PubMed
7. Su D, Van Rooijen N. The role of macrophages in the immunoadjuvant action of liposomes: effects of elimination of splenic macrophages on the immune response against intravenously injected liposome-associated albumin antigen. Immunology. 1989 Mar;66(3):466-70. PMID: 2703258; PMCID: PMC1385238. PubMed
8. Thepen T, Van Rooijen N, Kraal G. Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice. J Exp Med. 1989 Aug 1;170(2):499-509. doi: 10.1084/jem.170.2.499. PMID: 2526847; PMCID: PMC2189410. PubMed
